Tuberculosis

Tuberculosis: EndTB clinical trial for multidrug-resistant TB completes enrolment

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BOSTON/PARIS — Hundreds of patient volunteers from four continents have enrolled in a trial that aims to find safer, shorter, and effective treatments for multidrug-resistant tuberculosis (MDR-TB), an airborne, infectious disease that has grown resistant to standard medications. A group of scientists and clinicians led by Doctors Without Borders/Médecins Sans Frontières (MSF), Partners In Health (PIH), and Interactive … Read more

Ukraine: Fighting tuberculosis with medication, mental health and social support

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In Zhytomyr, Ukraine, our teams works with the Regional TB Dispensary to treat patients who have drug-resistant forms of tuberculosis (DR-TB). They are treated with a short course of DR-TB medication and the possibility of being treated at home most of the time; meaning patients can get back to their lives, families and careers sooner. Yet, completing … Read more

Access to Medicines: Lifesaving TB medicines still out of reach for children in high-burden countries

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Geneva – The World Health Organization (WHO) recently released new rapid guidance recommending that children of all ages with drug-resistant tuberculosis (DR-TB) have access to all-oral treatment using the drugs bedaquiline and/or delamanid. However, adopting these new recommendations in high TB burden countries requires access to the paediatric formulations of bedaquiline (produced by Johnson & Johnson) … Read more

COVID-19 in India: Tackling tuberculosis in the middle of coronavirus pandemic

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By Aparna Iyer, Project Medical Referent, MSF Drug-Resistant Tuberculosis Project in Mumbai MSF’s drug-resistant tuberculosis (DR-TB) and HIV project is located in the M-East Ward, one of the TB high-burden areas in Mumbai. During the second wave, there was a high number of COVID-19 cases being reported, about 6,000-7,000 cases a day which forced authorities … Read more

Tuberculosis: Sustainable solutions for children and adolescents at risk of drug-resistant TB

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They walked in single file through the narrow alleyways, winding away from their tin shack in Cape Town towards the health centre. Keitu – just 11 years old – carried her baby brother on her back since their mother was too frail and could barely manage on her own. Keitu kept a close eye on … Read more

Tuberculosis: Trial of multidrug-resistant TB treatment ends enrolment early after independent board indicates new regimen is superior

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LONDON – A trial aiming to find a better treatment for multidrug-resistant tuberculosis (MDR-TB) has stopped enrolling patients early after its independent data safety and monitoring board indicated that the regimen being studied is superior to current care, and more patient data was extremely unlikely to change the trial’s outcome. TB-PRACTECAL, a phase II/III clinical … Read more

Step UP For TB: Report shows new tests and drugs for world’s deadliest infectious disease remain out of reach

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MSF calls on governments and donors to step up and speed up TB testing and treatment Geneva — As the COVID-19 pandemic threatens to derail the global response to tuberculosis (TB), Doctors Without Borders/Médecins Sans Frontières (MSF) called on governments to accelerate testing, treatment, and prevention for TB, and called on donors to provide the … Read more

endTB trial: First patient enrolls for clinical trials of novel, short and all-oral regimens for multidrug-resistant tuberculosis in India

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Pune, India: Doctors Without Borders/ Médecins Sans Frontières (MSF) in collaboration with Indian Council for Medical Research (ICMR)- National AIDS Research Institute (NARI) and Department of Health Service, Government of Maharashtra is initiating two major clinical trials that aim at generating clinical evidence on the safety and efficacy of novel, short and all-oral regimens for the most difficult-to-treat … Read more

Tuberculosis: MSF welcomes WHO revision in TB guidelines and urges greater access and affordability in India to new regimen

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New Delhi, India: Doctors Without Borders/Medecins Sans Frontieres (MSF) has welcomed the revision made by the World Health Organisation (WHO) to its tuberculosis (TB) guidelines, allowing for safe use of a treatment regimen including both bedaquiline and delamanid for drug-resistant tuberculosis (DR-TB) patients, while urging a faster uptake in India for patients with extensively drug-resistant … Read more